- One method is to build a long sky bridge below the height where harpies and wyverns spawn, preferably out of asphalt blocks. Using weapons that do damage quickly like the Megashark or the Piranha Gun while running along the sky bridge works very well, it just requires patience.
- Another method is to use a teleporter wired to a 1-second timer along with a hall of spike ball traps. When executed properly, the Dungeon Guardian(s) will chase you as you teleport back and forth, taking damage from the spike balls. This method is effortless and saves bullets and gravitation potions.
- A full set of Frost Armor is also very good, considering the fact that it is not immune to the Frostburn debuff.
- Using Vampire Knives to shoot more than one knife at a time infinitely may be a good idea, although these will need to be obtained from another Dungeon's Crimson Chest.
- Using a Black Belt or Master Ninja Gear can save your life on accidental mishaps a tenth (10% chance to dodge) of the time.
- The Rod of Discord is capable of teleporting you out of sticky situations, but should not be overused due to the Chaos State debuff.
- The buff from the Titanium armor can sometimes help if the dungeon guardian hits you after the buff activates.
- Wearing Turtle Armor, Black Belt, and Master Ninja Gear will greatly help you kill them.
- Originally, actual Skeletron Heads were used to guard the Dungeon. Killing all Skeletron Heads would count as defeating Skeletron, so the Dungeon Guardian was created to repair this unintentional behavior.
- If you continue going down into the Dungeon, and manage to dodge the first Dungeon Guardian, more may appear and eventually, quickly kill you due to their immense speed.
- If you teleport out with a Magic Mirror at the exact moment that a the Dungeon Guardian hits you, a death message will be displayed but you will survive.
- 126.96.36.199.1: Damaged reduced from 9000 to 1000, to prevent Turtle armor from dealing too much damage, however the exploit still works due to the Dungeon Guardian's AI resetting the damage.
- 1.2: Now drops a Bone Key upon death.
- 1.0.5: Introduced, replacing Skeletron Heads as the Dungeon's guards.
- 1.0.5 Patchlog: “Entering the dungeon before defeating Skeletron now spawns a new NPC instead of Skeletron’s head. This should fix several issues with that event.”